Rated 4.6 out of 1,747 Reviews

Allergy Asthma Clean Allergen Spray Refill 2 Pack 64oz by Allergy Defender

Name: Allergy Asthma Clean Allergen Spray Refill 2 Pack 64oz by Allergy Defender
Brand: Allergy Defender
SKU: refill1
Price: 19.99 USD
Availability: InStock

$19.99 USD

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Goodbye Pet Dander, Dust Mites & More. These are the “allergens” hiding in carpets, bedding, and the air—tiny particles that cause everyday discomfort. Our chemist-developed, third-party verified, science-backed formula neutralizes them in minutes, so you can enjoy your family & pets in comfort. And it's as easy as spraying your house.

Not a medication or device—just spray your home
Chemist-developed formula made with natural mineral ingredients
Verified by third-party testing, shown to reduce allergens by up to 99%*
Covers up to 2,400 sf; spray into the air and on surfaces
Includes 2 refill packets—use your own bottle & just add water
Created by a father to protect his asthmatic daughter after she almost died from an allergic asthma attack brought on by two "hypoallergenic" poodles.

Ingredients

Our Ingredients: FDA & GRAS pure sodium sesquicarbonate, FDA food grade mineral phosphate salts. No harsh chemicals, no fragrances, no bad stuff. Just real ingredients you find in the foods you already eat everyday.

Backed by Science

We contracted with INBIO to get lab verified results to ensure our product was safe and effective for allergy sufferers worldwide. Surface testing up to 99% Reduction of Major Allergens

Air testing up to 95% to 80% Reduction of Major Allergens

Made for Pet Owners

Our Allergen Spray is made for real homes with real families — pets included. We use only clean, mineral-based ingredients, never harsh chemicals or fragrances. That’s why thousands of pet families trust it to help create a more comfortable home for everyone.

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"Life Changing" "Loved this product" "1000% works" "This stuff works. Period."

Users who report significant relief from allergy symptoms

Allergens Don’t Belong in Your Home. Neutralize them Naturally

Your home is filled with hidden allergens like cat dander, dog dander, and dust mite allergens.

Cat Dander

The main allergen is a protein called Fel d 1, found in cats’ saliva, skin, and dander. Even hairless cats produce it, and it easily spreads through the air and onto surfaces.
Dog Dander

Can f 1 is one of primary allergen found in dogs. It’s a protein produced in their skin, saliva, and even urine. Even low-shedding or “hypoallergenic” breeds still release this allergen into their environment.
Dust Mites

Der p 1 & Der f 1 are the proteins from dust mite waste and body parts. They are found in soft surfaces throughout your home. 80% of homes contain dust mite allergens in their beds.

Ingredients: FDA & GRAS pure sodium sesquicarbonate, FDA food grade mineral phosphate salts.No proteins, enzymes, essential oils, or harsh chemicals.

Natural, harsh chemical-free, and perfect for cats and dogs. Made by pet owners for pet owners.

No perfumes or masking scents. Clean, neutral protection that won’t irritate you.

Each refill packet treats up to 1,200 sf or lasts up to 60 days of targeted use.

Use your own 32/33 oz clean bottle and refill as often as needed.

Cleaning Misses, Purifiers Fall Short, and Quick Fix Options Work Too Late

Allergens like pet dander and dust mites don’t go away easily. They can stay active for months—clinging to furniture, bedding, and carpets, while floating unseen in the air. Purifiers only treat the air that passes through them, leaving surfaces untouched. Daily cleaning can stir up allergens and medications only help after discomfort has begun. Allergen Spray works differently, neutralizing allergens at the source in the air and on surfaces in your home, working before the allergens can cause you trouble.

Allergen Spray in action

An Easy Ritual For

powerful results in as little as minutes a day.

The Only Mineral Breakthrough Proven to Deactivate Allergens at the Source

For decades, allergen management has relied on partial solutions — filters that trap particles after they’re already airborne, constant cleaning that never truly keeps up, and medications that only treat the aftermath. Allergen Spray is the first lab-verified mineral breakthrough designed to neutralize allergens at the molecular level— preventing them from causing discomfort before the reaction even begins.

Our mineral blend, composed of FDA-recognized GRAS compounds, immediately binds to allergenic proteins such as Fel d 1 (cat dander), Can f 1 (dog dander), Der p 1 (dust mites), and Bla g 1 (cockroaches). This ionic interaction encapsulates the proteins, disrupting their stability and rendering them less biologically active.

Allergens are not just dust — they are highly stable proteins capable of surviving in fabrics, carpets, and the air. Allergy Defender alters their structural integrity,denaturing the proteins so they can no longer effectively cause you discomfort.

Once encapsulated and destabilized, allergens aggregate and fall out of the air. On surfaces, they lose their ability to become re-aerosolized, cutting off the cycle of constant exposure that fuels allergy discomfort.

Up to 99% effective*

20+ Years of Research & Science in One Powerful Spray

Allergy Defender contracted with Inbio to get lab verified results to ensure our product was safe and effective for allergen sufferers worldwide.

The analysis method used: Multiplex Array for Indoor Allergens (MARIA®) 5-plex

What is MARIA: MARIA is an antibody-based immunoassay method developed by InBio utilizing Luminex xMAP® technology. The method has been validated through an international, multi-center trial, and the percent reduction of allergens is based on allergen concentration measured using the MARIA assay.

The Results for Air & Surface

AIR: Air testing shows up to 95% Reduction of Major Allergens*

Based on the results from testing air samples collected from an environmental chamber, Allergen Spray effectively reduces dust mite, cat, and dog allergens after being sprayed in the air.

Surface: Surface testing up to 99% Reduction of Major Allergens*

Based on the results from surface samples collected from multiple testing procedures, Allergen Spray effectively reduces the number of allergens from dust mite and cockroach matter, and cat and dog dander from surfaces after being treated.

The result? Fresher air: up to 99%* fewer allergens.

No irritants. designed for safety.

Why Minerals Are the Gold Standard in Allergen Control

Allergen Spray addresses allergen proteins at the source with a 100% mineral-based formula—3rd-party lab verified to reduce up to 99%* of allergens on surfaces and up to 95%* in the air.

Our all-mineral approach means zero fragrances, zero harsh chemicals, and zero plant proteins. Made with FDA GRAS food-grade minerals, it's designed to be perfect for use around kids, pets, and people with sensitivities.

Developed by a father for his daughter who has asthma. Family-owned, family-focused.

founded out of love

My Father's Promise to his Asthmatic Daughter

I almost died from an allergy-induced asthma attack brought on by two hypoallergenic poodles at the age of five. My father promised me he would never stop searching for a solution to help me. And he kept that promise. Together with a team of chemists, he formulated a product that changed my entire life. Today, that product has helped over 300,000 customers.

Individual results may vary. Reviews are the honest opinions of customers and are not intended to represent medical claims. This product is a household cleaner and is not a substitute for medical treatment or medication.

Frequently asked questions

Can I mix it with tap water?

Yes — any water works, including tap water.

Just fill your bottle, pour in the refill packet, and shake until dissolved.

Does it work in the air as well as on surfaces?

Yes — you can use it on both.

A light mist sprayed upward helps neutralize airborne allergens.

How do I store the refill packets and the mixed spray?

Store packets in a cool, dry place.

After mixing, the spray is stable — just shake gently before each use to keep minerals fully dispersed.

How quickly does it start working?

Once sprayed, the minerals begin neutralizing allergens within minutes on both surfaces and in the air.

Is it safe for people and pets?

The formula uses pure minerals that fall under the FDA GRAS category.

There are no fragrances, no VOCs, no irritants, and no harsh chemicals.

It was originally created for individuals with sensitivities in mind.

What type of bottle and sprayer can I use?

Any clean 32 or 33 oz spray bottle works well.

A standard trigger sprayer is perfect — no special equipment needed.

*Based on independent third-party laboratory testing

*Based on independent third-party laboratory testing, when used as directed

How many packets do I get?

For the Refill 2-Pack, you’ll receive two refills, providing more than 64 ounces of solution. Just pour into your own bottle and use your existing sprayer.

For the Refill 4-Pack, you’ll receive four refills, giving you over 128 ounces of solution to use as needed.

Why do I have to add my own water?

We discovered that shipping water increased our carbon emissions and hurt the planet. By adding your own water you are protecting mother earth and staying sustainable.

Any type of water is fine, we usually recommend just using water from your ta

Where and how often do I have to spray?

Here is a breakdown of how often and where you should spray in your household.

HOW OFTEN:

Severe pet allergens: Use daily

Dust mite allergens: Use 3x time a week

Visitors have pet allergens: Use before and during

Moved to a new place: Use weekly

Light pet allergens: Use weekly

Dust bothers me: Use weekly

WHERE TO SPRAY:

In the air: Mist every room in your home

Soft surfaces: Upholstery, pet bedding, couch, bedding, pillows, curtains, carpet, mattress, most soft surfaces

Hard surfaces: Floors, walls, baseboards

Filters: Air filters, HVAC, vacuum cleaner

Other: Car, RV, hotel room

What are allergens?

Allergens are substances that can cause an allergic reaction. The most common allergens are proteins found in dust mites, pollen, mold, dust, and animal dander. When these proteins come into contact with the mucous membranes of the nose or eyes, they can trigger an immune response. The body produces antibodies to fight off allergens, which can lead to symptoms such as sneezing, watery eyes, and a runny nose.

What are the ingredients and are they lab tested?

Our Ingredients: FDA GRAS (Generally Recognized as Safe) Pure Sodium Sesquicarbonate, FDA Food Grade Mineral Phosphate Salts, and a touch of love.

No plant or enzyme-based ingredients, that could possibly trigger an allergic reaction.

Yes. Our ingredients are lab tested by the world leader in allergen detection systems, INBIO.

We spent 10+ years in research and development and have helped hundreds of thousands of customers. We utilize 3rd party testing to verify the safety and performance of our products continually.

How does the spray actually work?

Our unique mixture activates with water, and when atomized in a spray, attracts and attaches to allergen molecules and proteins in the air and on surfaces where they bring them down, encapsulate, and neutralize them- all with minerals.